MolNFT v1 · #155868 · protein
Crystal structure of isocitrate dehydrogenase 1 from phaeodactylum tricornutum
6LKZ: “Crystal structure of isocitrate dehydrogenase 1 from phaeodactylum tricornutum”. X-ray diffraction, 11 pockets (best druggability 0.81). MolNFT v1 #155868 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LKZ
- Type
- protein
- Length
- 964 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Isocitrate dehydrogenase
- Pockets
- 11 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, D | Isocitrate dehydrogenase | protein | 482 | 46% helix, 18% strand | — |
Pockets
11 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 774 | 0.81 | 0.84 | 68 | empty |
| 2 | 456 | 0.59 | 0.75 | 57 | empty |
| 3 | 361 | 0.59 | 0.76 | 29 | empty |
| 4 | 331 | 0.57 | 0.76 | 40 | empty |
| 5 | 143 | 0.55 | 0.81 | 21 | empty |
Interfaces
1 interface between chains.
- C–D · 4173 Ų buried · 59 hydrogen bonds · protein-protein
Compared structures
- 6LKZ · Crystal structure of isocitrate dehydrogenase 1 from Phaeodactylum tricornutum · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6LKZ · PDBe 6LKZ
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