MolNFT v1 · #155863 · protein

Crystal structure of the Fab fragment of murine monoclonal antibody kh-1 against human herpesvirus 6B

6LKT · Antibody Fab fragment H chain: “Crystal structure of the Fab fragment of murine monoclonal antibody kh-1 against human herpesvirus 6B”. X-ray diffraction, 4 pockets (best druggability 0.58). MolNFT v1 #155863 on GenesisL1: 3D…

PDB: 6LKT
Type: protein
Length: 427 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Antibody Fab fragment H chain; Antibody Fab fragment L-chain
Pockets: 4 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Antibody Fab fragment H chain	protein	217	8% helix, 53% strand	—
B	Antibody Fab fragment L-chain	protein	210	6% helix, 52% strand	—

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	464	0.58	0.74	51	empty
2	79	0.51	0.85	23	empty
3	123	0.41	0.75	20	empty
4	53	0.25	0.72	15	empty

Interfaces

1 interface between chains.

A–B · 1838 Å² buried · 18 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

6LKT · Crystal structure of the Fab fragment of murine monoclonal antibody KH-1 against Human… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6LKT · PDBe 6LKT

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