MolNFT v1 · #155784 · protein
A quinone oxidoreductase
6LII · Synaptic vesicle membrane protein vat-1 homolog: “A quinone oxidoreductase”. X-ray diffraction, 16 pockets (best druggability 0.81). MolNFT v1 #155784 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LII
- Type
- protein
- Length
- 1,372 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Synaptic vesicle membrane protein vat-1 homolog
- UniProt
- Q99536
- Pockets
- 16 · best druggability 0.81
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Synaptic vesicle membrane protein vat-1 homolog | protein | 345 | 32% helix, 28% strand | Q99536 |
| B | Synaptic vesicle membrane protein vat-1 homolog | protein | 340 | 33% helix, 28% strand | Q99536 |
| D | Synaptic vesicle membrane protein vat-1 homolog | protein | 342 | 33% helix, 28% strand | Q99536 |
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.81 | 0.94 | 49 | empty |
| 2 | 133 | 0.80 | 0.97 | 35 | empty |
| 3 | 114 | 0.79 | 0.98 | 29 | empty |
| 4 | 302 | 0.77 | 0.88 | 53 | empty |
| 5 | 485 | 0.64 | 0.77 | 48 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1704 Ų buried · 32 hydrogen bonds · protein-protein
- C–D · 1658 Ų buried · 28 hydrogen bonds · protein-protein
- B–D · 449 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99536
- Elsewhere: RCSB PDB 6LII · PDBe 6LII · UniProt Q99536
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