MolNFT v1 · #155768 · protein

Structure of N-terminal and C-terminal domains of fanca

6LHW · Fanconi anemia complementation group a: “Structure of N-terminal and C-terminal domains of fanca”. Electron microscopy, 20 pockets (best druggability 0.71). MolNFT v1 #155768 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6LHW
Type: protein
Length: 1,541 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi anemia complementation group a
Pockets: 20 · best druggability 0.71

Structure

electron microscopy · 3 distinct chains · 48% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Fanconi anemia complementation group a	protein	310	50% helix, 0% strand	—
B	Fanconi anemia complementation group a	protein	566	49% helix, 0% strand	—
A	Fanconi anemia complementation group a	protein	665	45% helix, 1% strand	—

Pockets

20 pockets found on a 1 Å grid, 13 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	389	0.71	0.83	59	empty
2	354	0.70	0.83	64	empty
3	358	0.69	0.82	75	empty
4	281	0.66	0.82	54	empty
5	552	0.66	0.77	73	empty

Interfaces

3 interfaces between chains.

B–A · 927 Å² buried · 2 hydrogen bonds · protein-protein
C–A · 361 Å² buried · 4 hydrogen bonds · protein-protein
C–B · 29 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6LHW · Structure of N-terminal and C-terminal domains of FANCA · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6LHW · PDBe 6LHW

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