MolNFT v1 · #155767 · protein

Structure of fanca and fancg complex

6LHV · Fanconi anemia complementation group G: “Structure of fanca and fancg complex”. Electron microscopy, 20 pockets (best druggability 0.78). MolNFT v1 #155767 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6LHV
Type: protein
Length: 1,707 residues
Chains: 3
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi anemia complementation group G; Fanconi anemia complementation group a
Pockets: 20 · best druggability 0.78

Structure

electron microscopy · 3 distinct chains · 51% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
C	Fanconi anemia complementation group G	protein	319	68% helix, 0% strand	—
B	Fanconi anemia complementation group a	protein	671	49% helix, 0% strand	—
A	Fanconi anemia complementation group a	protein	717	46% helix, 1% strand	—

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	743	0.78	0.83	139	empty
2	421	0.72	0.83	71	empty
3	410	0.71	0.82	74	empty
4	387	0.70	0.82	72	empty
5	728	0.67	0.75	100	empty

Interfaces

2 interfaces between chains.

B–A · 992 Å² buried · 1 hydrogen bond · protein-protein
C–A · 79 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6LHV · Structure of FANCA and FANCG Complex · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 6LHV · PDBe 6LHV

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