MolNFT v1 · #155766 · protein

High resolution structure of fanca C-terminal domain (ctd)

6LHU · Fanconi anemia complementation group a: “High resolution structure of fanca C-terminal domain (ctd)”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #155766 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 6LHU
Type: protein
Length: 1,518 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fanconi anemia complementation group a
UniProt: Q4VT51
Pockets: 20 · best druggability 0.81

Structure

electron microscopy · 2 distinct chains · 48% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Fanconi anemia complementation group a	protein	807	49% helix, 0% strand	Q4VT51
A	Fanconi anemia complementation group a	protein	711	46% helix, 1% strand	Q4VT51

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1034	0.81	0.82	93	empty
2	998	0.77	0.79	87	empty
3	150	0.77	0.95	34	empty
4	352	0.73	0.84	53	empty
5	80	0.73	0.96	17	empty

Interfaces

1 interface between chains.

B–A · 3048 Å² buried · 26 hydrogen bonds · protein-protein

Compared structures

6LHU · High resolution structure of FANCA C-terminal domain (CTD) · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4VT51
Elsewhere: RCSB PDB 6LHU · PDBe 6LHU · UniProt Q4VT51

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