MolNFT v1 · #155758 · protein
Structure of human PYCR2
6LHM · Pyrroline-5-carboxylate reductase 2: “Structure of human PYCR2”. X-ray diffraction, 12 pockets (best druggability 0.81). MolNFT v1 #155758 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6LHM
- Type
- protein
- Length
- 1,317 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pyrroline-5-carboxylate reductase 2
- EC
- 1.5.1.2
- UniProt
- Q96C36
- Pockets
- 12 · best druggability 0.81
Structure
x-ray diffraction · 5 distinct chains · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2) | protein | 268 | 55% helix, 11% strand | Q96C36 |
| B | Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2) | protein | 269 | 52% helix, 12% strand | Q96C36 |
| C | Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2) | protein | 258 | 51% helix, 11% strand | Q96C36 |
| D | Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2) | protein | 273 | 57% helix, 11% strand | Q96C36 |
| E | Pyrroline-5-carboxylate reductase 2 (EC 1.5.1.2) | protein | 249 | 51% helix, 11% strand | Q96C36 |
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 971 | 0.81 | 0.82 | 92 | empty |
| 2 | 749 | 0.77 | 0.81 | 82 | empty |
| 3 | 552 | 0.72 | 0.80 | 60 | empty |
| 4 | 613 | 0.69 | 0.78 | 49 | empty |
| 5 | 461 | 0.57 | 0.73 | 39 | empty |
Interfaces
7 interfaces between chains.
- A–D · 4541 Ų buried · 23 hydrogen bonds · protein-protein
- C–E · 4490 Ų buried · 13 hydrogen bonds · protein-protein
- C–D · 633 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 405 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 387 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96C36
- Elsewhere: RCSB PDB 6LHM · PDBe 6LHM · UniProt Q96C36
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