MolNFT v1 · #155739 · protein
Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an inward-facing apo-state
6LH0 · Transporter, SODIUM/BILE acid symporter family: “Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid transporter in an…”. X-ray diffraction, 1 ligand (A6L), 5 pockets (best druggability 0.71). MolNFT v1…
- PDB
- 6LH0
- Type
- protein
- Length
- 308 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transporter, SODIUM/BILE acid symporter family
- UniProt
- A0A380PV03
- Ligands
- A6L
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 81% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transporter, SODIUM/BILE acid symporter family | protein | 308 | 81% helix, 1% strand | A0A380PV03 |
Ligands and binding sites
- A6L · 2,3-dihydroxypropyl (9Z)-octadec-9-enoate · ligand · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 53 | 0.71 | 0.98 | 23 | empty |
| 2 | 244 | 0.60 | 0.80 | 29 | empty |
| 3 | 66 | 0.45 | 0.83 | 17 | empty |
| 4 | 119 | 0.44 | 0.76 | 18 | empty |
| 5 | 54 | 0.29 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6LH0 · Crystal structure of a cysteine-pair mutant (P10C-S291C) of a bacterial bile acid… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A380PV03
- Elsewhere: RCSB PDB 6LH0 · PDBe 6LH0 · UniProt A0A380PV03
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