MolNFT v1 · #155732 · protein
The crystal complex structure of histidine kinase and response regulator
6LGQ · Histidine kinase kdpd: “The crystal complex structure of histidine kinase and response regulator”. X-ray diffraction, 5 pockets (best druggability 0.70). MolNFT v1 #155732 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6LGQ
- Type
- protein
- Length
- 441 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histidine kinase kdpd; DNA-binding response regulator
- EC
- 2.7.13.3
- UniProt
- A0A069C8B3, A0A061KF22
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Histidine kinase kdpd (EC 2.7.13.3) | protein | 221 | 45% helix, 18% strand | A0A069C8B3 |
| D | DNA-binding response regulator | protein | 220 | 36% helix, 21% strand | A0A061KF22 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 625 | 0.70 | 0.78 | 48 | empty |
| 2 | 106 | 0.46 | 0.80 | 30 | empty |
| 3 | 80 | 0.41 | 0.79 | 21 | empty |
| 4 | 87 | 0.36 | 0.75 | 17 | empty |
| 5 | 63 | 0.29 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- C–D · 1708 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 6LGQ · The crystal complex structure of histidine kinase and response regulator · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A069C8B3
- Every structure of UniProt A0A061KF22
- Elsewhere: RCSB PDB 6LGQ · PDBe 6LGQ · UniProt A0A069C8B3 · UniProt A0A061KF22
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