MolNFT v1 · #15569 · protein

The crystal structure of phosphoglucose isomerase from rabbit muscle

1N8T · Glucose-6-phosphate isomerase: “The crystal structure of phosphoglucose isomerase from rabbit muscle”. X-ray diffraction, 10 pockets (best druggability 0.78). MolNFT v1 #15569 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1N8T
Type: protein
Length: 1,114 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glucose-6-phosphate isomerase
EC: 5.3.1.9
UniProt: Q9N1E2
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Glucose-6-phosphate isomerase (EC 5.3.1.9)	protein	557	53% helix, 12% strand	Q9N1E2

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	967	0.78	0.80	65	empty
2	446	0.72	0.82	53	empty
3	521	0.72	0.81	53	empty
4	143	0.41	0.74	24	empty
5	51	0.40	0.82	13	empty

Interfaces

1 interface between chains.

A–B · 6807 Å² buried · 91 hydrogen bonds · protein-protein

Compared structures

1N8T · The crystal structure of phosphoglucose isomerase from rabbit muscle · the same entry in another collection · chain A against A, TM-score 1.00
Q9N1E2 · AlphaFold monomer V2.0 prediction for glucose-6-phosphate isomerase (Q9N1E2) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9N1E2
Elsewhere: RCSB PDB 1N8T · PDBe 1N8T · UniProt Q9N1E2

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