MolNFT v1 · #155565 · protein

Structure of rat gld-2 (terminal nucleotidyltransferase 2, TENT2)

6LBK · POLY(A) RNA polymerase GLD2: “Structure of rat gld-2 (terminal nucleotidyltransferase 2, TENT2)”. X-ray diffraction, 5 pockets (best druggability 0.74). MolNFT v1 #155565 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6LBK
Type: protein
Length: 644 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: POLY(A) RNA polymerase GLD2
EC: 2.7.7.19
UniProt: Q5U315
Pockets: 5 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	POLY(A) RNA polymerase GLD2 (EC 2.7.7.19)	protein	325	48% helix, 14% strand	Q5U315
B	POLY(A) RNA polymerase GLD2 (EC 2.7.7.19)	protein	319	47% helix, 14% strand	Q5U315

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	815	0.74	0.78	59	empty
2	762	0.70	0.77	52	empty
3	54	0.30	0.75	11	empty
4	63	0.29	0.74	16	empty
5	53	0.27	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 606 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6LBK · Structure of rat GLD-2 (Terminal nucleotidyltransferase 2, TENT2) · the same entry in another collection · chain A against A, TM-score 1.00
Q5U315 · AlphaFold monomer V2.0 prediction for POLY(A) RNA polymerase GLD2 (Q5U315) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5U315
Elsewhere: RCSB PDB 6LBK · PDBe 6LBK · UniProt Q5U315

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