MolNFT v1 · #155511 · protein
Crystal structure of mouse tifa (T9E/C36S mutant)
6L9W · Traf-interacting protein with fha domain-containing protein…: “Crystal structure of mouse tifa (T9E/C36S mutant)”. X-ray diffraction, 8 pockets (best druggability 0.74). MolNFT v1 #155511 on GenesisL1: 3D structure, binding sites…
- PDB
- 6L9W
- Type
- protein
- Length
- 837 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Traf-interacting protein with fha domain-containing protein a
- UniProt
- Q793I8
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 4 distinct chains · 1% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Traf-interacting protein with fha domain-containing protein a | protein | 138 | 0% helix, 50% strand | Q793I8 |
| C | Traf-interacting protein with fha domain-containing protein a | protein | 139 | 0% helix, 48% strand | Q793I8 |
| D, E | Traf-interacting protein with fha domain-containing protein a | protein | 142 | 2% helix, 43% strand | Q793I8 |
| F | Traf-interacting protein with fha domain-containing protein a | protein | 138 | 2% helix, 48% strand | Q793I8 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 615 | 0.74 | 0.81 | 60 | empty |
| 2 | 366 | 0.69 | 0.82 | 46 | empty |
| 3 | 365 | 0.56 | 0.74 | 30 | empty |
| 4 | 117 | 0.53 | 0.82 | 21 | empty |
| 5 | 74 | 0.46 | 0.82 | 14 | empty |
Interfaces
10 interfaces between chains.
- E–F · 1147 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1122 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 1116 Ų buried · 20 hydrogen bonds · protein-protein
- B–D · 655 Ų buried · 13 hydrogen bonds · protein-protein
- D–E · 291 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 6L9W · Crystal structure of mouse TIFA (T9E/C36S mutant) · the same entry in another collection · chain F against F, TM-score 1.00
- Q793I8 · AlphaFold monomer V2.0 prediction for traf-interacting protein with fha domain-containing… · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q793I8
- Elsewhere: RCSB PDB 6L9W · PDBe 6L9W · UniProt Q793I8
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