MolNFT v1 · #155457 · protein
The sodium-dependent phosphate transporter
6L85: “The sodium-dependent phosphate transporter”. X-ray diffraction, 2 ligands (NA, PO4), 6 pockets (best druggability 0.82). MolNFT v1 #155457 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6L85
- Type
- protein
- Length
- 801 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphate transporter
- UniProt
- R4NN92
- Ligands
- NA, PO4
- Pockets
- 6 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphate transporter | protein | 400 | 81% helix, 1% strand | R4NN92 |
| B | Phosphate transporter | protein | 401 | 83% helix, 0% strand | R4NN92 |
Ligands and binding sites
- NA · Sodium ion · metal · 6 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
- PEG · Di(hydroxyethyl)ether · additive · 11 copies · chains A, B
- LMT · Dodecyl-beta-D-maltoside · additive · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1107 | 0.82 | 0.82 | 100 | PEG, LMT |
| 2 | 304 | 0.72 | 0.84 | 30 | empty |
| 3 | 70 | 0.50 | 0.84 | 18 | empty |
| 4 | 87 | 0.41 | 0.78 | 14 | empty |
| 5 | 81 | 0.38 | 0.76 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1313 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6L85 · The sodium-dependent phosphate transporter · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt R4NN92
- Elsewhere: RCSB PDB 6L85 · PDBe 6L85 · UniProt R4NN92
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