MolNFT v1 · #155453 · protein
Crystal structure of pombe MOD21 N-terminus and MOZART1
6L80 · Gamma-tubulin complex subunit MOD21: “Crystal structure of pombe MOD21 N-terminus and MOZART1”. X-ray diffraction, 1 pocket (best druggability 0.56). MolNFT v1 #155453 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6L80
- Type
- protein
- Length
- 317 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-tubulin complex subunit MOD21; Mitotic-spindle organizing protein 1
- UniProt
- Q9UT52
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gamma-tubulin complex subunit MOD21 | protein | 102 | 75% helix, 0% strand | Q9UT52 |
| B | Mitotic-spindle organizing protein 1 | protein | 54 | 72% helix, 0% strand | — |
| C | Gamma-tubulin complex subunit MOD21 | protein | 107 | 77% helix, 0% strand | Q9UT52 |
| D | Mitotic-spindle organizing protein 1 | protein | 54 | 70% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.56 | 0.76 | 35 | empty |
Interfaces
4 interfaces between chains.
- A–B · 2104 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 2079 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 411 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 11 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6L80 · Crystal structure of pombe Mod21 N-terminus and Mozart1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UT52 · AlphaFold monomer V2.0 prediction for gamma-tubulin complex subunit MOD21 (Q9UT52) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UT52
- Elsewhere: RCSB PDB 6L80 · PDBe 6L80 · UniProt Q9UT52
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