MolNFT v1 · #155435 · protein
Signal substraction of TCDB1-TCCC2 and part of TCDA1
6L7I: “Signal substraction of TCDB1-TCCC2 and part of TCDA1”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #155435 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6L7I
- Type
- protein
- Length
- 3,022 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TCDA1; TCDB1; TCCC2
- UniProt
- Q9RN43, Q93EP6, Q93EP1
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 4 distinct chains · 6% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | TCDA1 | protein | 179 | 12% helix, 31% strand | Q9RN43 |
| F | TCDB1 | protein | 1451 | 7% helix, 40% strand | Q93EP6 |
| G | TCCC2 | protein | 660 | 2% helix, 47% strand | Q93EP1 |
| H | TCCC2 | protein | 16 | 19% helix, 13% strand | Q93EP1 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 958 | 0.80 | 0.82 | 69 | empty |
| 2 | 92 | 0.77 | 0.98 | 23 | empty |
| 3 | 510 | 0.68 | 0.79 | 48 | empty |
| 4 | 465 | 0.67 | 0.79 | 46 | empty |
| 5 | 584 | 0.65 | 0.76 | 60 | empty |
Interfaces
12 interfaces between chains.
- F–G · 4160 Ų buried · 61 hydrogen bonds · protein-protein
- A–E · 1107 Ų buried · 12 hydrogen bonds · protein-protein
- G–H · 1097 Ų buried · 16 hydrogen bonds · protein-protein
- C–D · 1094 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 1074 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6L7I · Signal substraction of TcdB1-TccC2 and part of TcdA1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9RN43
- Every structure of UniProt Q93EP6
- Every structure of UniProt Q93EP1
- Elsewhere: RCSB PDB 6L7I · PDBe 6L7I · UniProt Q9RN43 · UniProt Q93EP6 · UniProt Q93EP1
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