MolNFT v1 · #155422 · protein
Sirtuin 2 demyristoylation native final product
6L72 · NAD-dependent protein deacetylase sirtuin-2: “Sirtuin 2 demyristoylation native final product”. X-ray diffraction, 2 ligands (OMR, ZN), 2 pockets (best druggability 0.81). MolNFT v1 #155422 on GenesisL1: 3D structure, binding sites…
- PDB
- 6L72
- Type
- protein
- Length
- 294 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NAD-dependent protein deacetylase sirtuin-2
- EC
- 2.3.1.286
- UniProt
- Q8IXJ6
- Ligands
- OMR, ZN
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) | protein | 294 | 35% helix, 17% strand | Q8IXJ6 |
Ligands and binding sites
- OMR · [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate · ligand · chains A
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 471 | 0.81 | 0.88 | 60 | OMR |
| 2 | 77 | 0.32 | 0.75 | 21 | empty |
Compared structures
- 6L72 · Sirtuin 2 demyristoylation native final product · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IXJ6
- Elsewhere: RCSB PDB 6L72 · PDBe 6L72 · UniProt Q8IXJ6
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