MolNFT v1 · #155322 · protein

Crystal structure of metallo-beta-lactamase imp-27 from morganella morganii

6L3S · Imp-27 metallo-beta-lactamase: “Crystal structure of metallo-beta-lactamase imp-27 from morganella morganii”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.44). MolNFT v1 #155322 on GenesisL1: 3D structure…

PDB: 6L3S
Type: protein
Length: 436 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Imp-27 metallo-beta-lactamase
UniProt: A0A286S0G7
Ligands: ZN
Pockets: 6 · best druggability 0.44

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Imp-27 metallo-beta-lactamase	protein	218	28% helix, 31% strand	A0A286S0G7

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.44	0.76	32	empty
2	159	0.42	0.74	25	empty
3	144	0.42	0.75	24	ZN
4	79	0.42	0.79	17	empty
5	76	0.39	0.78	15	empty

Interfaces

1 interface between chains.

A–B · 384 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

6L3S · Crystal structure of metallo-beta-lactamase IMP-27 from Morganella morganii · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A286S0G7
Elsewhere: RCSB PDB 6L3S · PDBe 6L3S · UniProt A0A286S0G7

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