MolNFT v1 · #155226 · protein
Crystal structure of senecavirus a 3C protease
6L0T: “Crystal structure of senecavirus a 3C protease”. X-ray diffraction, 7 pockets (best druggability 0.62). MolNFT v1 #155226 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6L0T
- Type
- protein
- Length
- 412 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3C protease
- UniProt
- A0A1X9Q9H2
- Pockets
- 7 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3C protease | protein | 206 | 15% helix, 52% strand | A0A1X9Q9H2 |
| B | 3C protease | protein | 206 | 15% helix, 52% strand | A0A1X9Q9H2 |
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 90 | 0.62 | 0.89 | 24 | empty |
| 2 | 256 | 0.54 | 0.76 | 34 | empty |
| 3 | 152 | 0.47 | 0.77 | 19 | empty |
| 4 | 121 | 0.42 | 0.76 | 27 | empty |
| 5 | 67 | 0.39 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 781 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6L0T · Crystal structure of senecavirus A 3C protease · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A1X9Q9H2
- Elsewhere: RCSB PDB 6L0T · PDBe 6L0T · UniProt A0A1X9Q9H2
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