MolNFT v1 · #155194 · protein

Crystal structure of cytochrome P450MEL 107F1 in complex with heme and imidazole

6KZS · Cytochrome P-450: “Crystal structure of cytochrome P450MEL 107F1 in complex with heme and imidazole”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.87). MolNFT v1 #155194 on GenesisL1: 3D structure, binding sites…

PDB: 6KZS
Type: protein
Length: 396 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P-450
EC: 1.14.-.-
UniProt: Q4H2B8
Ligands: HEM
Pockets: 2 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P-450 (EC 1.14.-.-)	protein	396	53% helix, 11% strand	Q4H2B8

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · chains A
IMD · Imidazole · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	602	0.87	0.92	60	HEM, IMD
2	98	0.38	0.75	16	empty

Compared structures

6KZS · Crystal structure of cytochrome P450mel 107F1 in complex with heme and imidazole · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q4H2B8
Elsewhere: RCSB PDB 6KZS · PDBe 6KZS · UniProt Q4H2B8

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