MolNFT v1 · #155188 · protein
GLUK3 receptor complex with kainate
6KZM · Glutamate receptor ionotropic, kainate 3: “GLUK3 receptor complex with kainate”. Electron microscopy, 20 pockets (best druggability 0.89). MolNFT v1 #155188 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KZM
- Type
- protein
- Length
- 2,867 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor ionotropic, kainate 3
- UniProt
- G3V9I2
- Pockets
- 20 · best druggability 0.89
Structure
electron microscopy · 3 distinct chains · 39% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor ionotropic, kainate 3 | protein | 718 | 39% helix, 16% strand | G3V9I2 |
| B, C | Glutamate receptor ionotropic, kainate 3 | protein | 716 | 38% helix, 16% strand | G3V9I2 |
| D | Glutamate receptor ionotropic, kainate 3 | protein | 717 | 40% helix, 15% strand | G3V9I2 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1008 | 0.89 | 0.90 | 126 | empty |
| 2 | 1164 | 0.87 | 0.87 | 116 | empty |
| 3 | 978 | 0.86 | 0.87 | 108 | empty |
| 4 | 447 | 0.85 | 0.92 | 73 | empty |
| 5 | 691 | 0.84 | 0.88 | 77 | empty |
Interfaces
5 interfaces between chains.
- C–D · 3007 Ų buried · 39 hydrogen bonds · protein-protein
- A–B · 2694 Ų buried · 36 hydrogen bonds · protein-protein
- A–D · 1166 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 1089 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 463 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 6KZM · GluK3 receptor complex with kainate · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G3V9I2
- Elsewhere: RCSB PDB 6KZM · PDBe 6KZM · UniProt G3V9I2
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