MolNFT v1 · #155134 · protein
Crystal structural of active-site human glutathione-specific gamma- glutamylcyclotransferase 2(CHAC2) mutant with glutamate 74 replaced by glutamine
6KY0 · Glutathione-specific gamma-glutamylcyclotransferase 2: “Crystal structural of active-site human glutathione-specific gamma- glutamylcyclotransferase 2(CHAC2) mutant…”. X-ray diffraction, 5 pockets (best druggability 0.77). MolNFT v1…
- PDB
- 6KY0
- Type
- protein
- Length
- 518 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutathione-specific gamma-glutamylcyclotransferase 2
- EC
- 4.3.2.7
- UniProt
- Q8WUX2
- Pockets
- 5 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 27% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Glutathione-specific gamma-glutamylcyclotransferase 2 (EC 4.3.2.7) | protein | 180 | 29% helix, 36% strand | Q8WUX2 |
| C | Glutathione-specific gamma-glutamylcyclotransferase 2 (EC 4.3.2.7) | protein | 158 | 25% helix, 40% strand | Q8WUX2 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 768 | 0.77 | 0.81 | 71 | empty |
| 2 | 432 | 0.73 | 0.83 | 36 | empty |
| 3 | 356 | 0.58 | 0.76 | 36 | empty |
| 4 | 67 | 0.33 | 0.76 | 13 | empty |
| 5 | 62 | 0.32 | 0.76 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 462 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 271 Ų buried · 2 hydrogen bonds · protein-protein
- A–C · 94 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WUX2
- Elsewhere: RCSB PDB 6KY0 · PDBe 6KY0 · UniProt Q8WUX2
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