MolNFT v1 · #155036 · protein + RNA
Structure of influenza D virus polymerase bound to crna promoter in class 2
6KUV · Polymerase 3: “Structure of influenza D virus polymerase bound to crna promoter in class 2”. Electron microscopy, 20 pockets (best druggability 0.80). MolNFT v1 #155036 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KUV
- Type
- protein + RNA
- Length
- 1,663 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Polymerase 3; RNA-directed RNA polymerase catalytic subunit; Polymerase PB2; 3'-crna…
- EC
- 2.7.7.48
- UniProt
- K9LHJ4, K9LH03, K9LHF3
- Pockets
- 20 · best druggability 0.80
Structure
electron microscopy · 5 distinct chains · 41% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Polymerase 3 | protein | 686 | 40% helix, 12% strand | K9LHJ4 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 705 | 42% helix, 12% strand | K9LH03 |
| C | Polymerase PB2 | protein | 249 | 40% helix, 10% strand | K9LHF3 |
| R | 3'-crna | rna | 10 | — | — |
| V | 5'-crna | rna | 13 | — | — |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 498 | 0.80 | 0.87 | 54 | empty |
| 2 | 496 | 0.75 | 0.83 | 47 | empty |
| 3 | 769 | 0.75 | 0.80 | 95 | empty |
| 4 | 1035 | 0.74 | 0.77 | 78 | empty |
| 5 | 84 | 0.72 | 0.96 | 19 | empty |
Interfaces
9 interfaces between chains.
- A–B · 8197 Ų buried · 72 hydrogen bonds · protein-protein
- B–C · 5968 Ų buried · 29 hydrogen bonds · protein-protein
- A–C · 1604 Ų buried · 5 hydrogen bonds · protein-protein
- A–V · 1051 Ų buried · 16 hydrogen bonds · protein-nucleic
- A–R · 666 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 6KUV · Structure of influenza D virus polymerase bound to cRNA promoter in class 2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt K9LHJ4
- Every structure of UniProt K9LH03
- Every structure of UniProt K9LHF3
- Elsewhere: RCSB PDB 6KUV · PDBe 6KUV · UniProt K9LHJ4 · UniProt K9LH03 · UniProt K9LHF3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.