MolNFT v1 · #154930 · protein
Crystal structure of O-acetyl serine sulfhydrylase isoform 3 from entamoeba histolytica
6KR5 · Cysteine synthase 3: “Crystal structure of O-acetyl serine sulfhydrylase isoform 3 from entamoeba histolytica”. X-ray diffraction, 1 ligand (PLP), 5 pockets (best druggability 0.71). MolNFT v1 #154930 on GenesisL1: 3D structure…
- PDB
- 6KR5
- Type
- protein
- Length
- 671 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cysteine synthase 3
- EC
- 2.5.1.47
- UniProt
- Q401L7
- Ligands
- PLP
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cysteine synthase 3 (EC 2.5.1.47) | protein | 335 | 43% helix, 18% strand | Q401L7 |
| B | Cysteine synthase 3 (EC 2.5.1.47) | protein | 336 | 42% helix, 17% strand | Q401L7 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 576 | 0.71 | 0.79 | 63 | PLP |
| 2 | 432 | 0.68 | 0.80 | 51 | PLP |
| 3 | 78 | 0.54 | 0.86 | 20 | empty |
| 4 | 71 | 0.39 | 0.79 | 14 | empty |
| 5 | 54 | 0.27 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 3044 Ų buried · 36 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 cofactor, 2 disulfide (pyridoxal phosphate Schiff base, disulfide).
Compared structures
- 6KR5 · Crystal structure of O-Acetyl Serine Sulfhydrylase isoform 3 from Entamoeba histolytica · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q401L7
- Elsewhere: RCSB PDB 6KR5 · PDBe 6KR5 · UniProt Q401L7
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.