MolNFT v1 · #154842 · protein

Crystal structure of BRD4-BRMO2 in complex with H2A.ZK4ACK7AC peptide

6KO2 · Bromodomain-containing protein 4: “Crystal structure of BRD4-BRMO2 in complex with H2A.ZK4ACK7AC peptide”. X-ray diffraction. MolNFT v1 #154842 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6KO2
Type: protein
Length: 114 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain-containing protein 4; Histone H2A.Z peptide
UniProt: O60885

Structure

x-ray diffraction · 2 distinct chains · 63% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain-containing protein 4	protein	107	67% helix, 0% strand	O60885
B	Histone H2A.Z peptide	protein	7	0% helix, 0% strand	—

Interfaces

1 interface between chains.

A–B · 457 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (acetylation).

Compared structures

6KO2 · Crystal Structure of BRD4-Brmo2 in complex with H2A.ZK4acK7ac peptide · the same entry in another collection · chain A against A, TM-score 1.00
O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60885
Elsewhere: RCSB PDB 6KO2 · PDBe 6KO2 · UniProt O60885

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