MolNFT v1 · #1548 · protein

NMR structure of human mip-1A D26A, minimized average structure

1B53: “NMR structure of human mip-1A D26A, minimized average structure”. Solution nmr, 5 pockets (best druggability 0.33). MolNFT v1 #1548 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1B53
Type: protein
Length: 138 residues
Chains: 2
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mip-1A
UniProt: P10147
Pockets: 5 · best druggability 0.33

Structure

solution nmr · 1 distinct chain · 13% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Mip-1A	protein	69	13% helix, 0% strand	P10147

Pockets

5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	67	0.33	0.75	13	empty
2	57	0.30	0.75	15	empty
3	58	0.29	0.75	16	empty
4	52	0.28	0.74	15	empty
5	55	0.28	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 713 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide (disulfide).

Compared structures

1B53 · NMR structure of human mip-1A D26A, minimized average structure · the same entry in another collection · chain A against A, TM-score 1.00
P10147 · AlphaFold monomer V2.0 prediction for C-C motif chemokine 3 (P10147) · a predicted model of the same protein · chain A against A, TM-score 0.72

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10147
Elsewhere: RCSB PDB 1B53 · PDBe 1B53 · UniProt P10147

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