MolNFT v1 · #15474 · protein
Crystal structure of a monooxygenase from the gene actva-ORF6 of streptomyces coelicolor in complex with the ligand nanaomycin D
1N5V · Actva-ORF6 monooxygenase: “Crystal structure of a monooxygenase from the gene actva-ORF6 of streptomyces coelicolor in complex with the…”. X-ray diffraction, 1 ligand (NOM), 3 pockets (best druggability 0.67). MolNFT v1 #15474 on…
- PDB
- 1N5V
- Type
- protein
- Length
- 224 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Actva-ORF6 monooxygenase
- UniProt
- Q53908
- Ligands
- NOM
- Pockets
- 3 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Actva-ORF6 monooxygenase | protein | 112 | 31% helix, 35% strand | Q53908 |
Ligands and binding sites
- NOM · 7-hydroxy-5-methyl-3,3A,5,11B-tetrahydro-1,4-dioxa-cyclopenta[a]anthracene-2,6,11-trione · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 118 | 0.67 | 0.89 | 24 | empty |
| 2 | 167 | 0.59 | 0.82 | 25 | NOM |
| 3 | 85 | 0.38 | 0.76 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1629 Ų buried · 36 hydrogen bonds · protein-protein
Compared structures
- 1N5V · Crystal structure of a Monooxygenase from the gene ActVA-Orf6 of Streptomyces coelicolor… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q53908
- Elsewhere: RCSB PDB 1N5V · PDBe 1N5V · UniProt Q53908
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