MolNFT v1 · #154724 · protein
Crystal structure of MAGI2-dendrin complex
6KKG · Membrane-associated guanylate kinase, ww and PDZ domain…: “Crystal structure of MAGI2-dendrin complex”. X-ray diffraction, 1 pocket (best druggability 0.67). MolNFT v1 #154724 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6KKG
- Type
- protein
- Length
- 214 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Membrane-associated guanylate kinase, ww and PDZ domain- containing protein 2; Peptide…
- UniProt
- Q9WVQ1, Q80TS7
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Membrane-associated guanylate kinase, ww and PDZ domain- containing protein 2 | protein | 87 | 16% helix, 33% strand | Q9WVQ1 |
| C, D | Peptide from dendrin | protein | 20 | 0% helix, 5% strand | Q80TS7 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 360 | 0.67 | 0.81 | 46 | empty |
Interfaces
4 interfaces between chains.
- B–D · 912 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 910 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 881 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 55 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6KKG · Crystal structure of MAGI2-Dendrin complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WVQ1 · AlphaFold monomer V2.0 prediction for membrane-associated guanylate kinase, ww and PDZ… · a predicted model of the same protein · chain A against A, TM-score 0.72
- Q80TS7 · AlphaFold monomer V2.0 prediction for dendrin (Q80TS7) · a predicted model of the same protein · chain C against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WVQ1
- Every structure of UniProt Q80TS7
- Elsewhere: RCSB PDB 6KKG · PDBe 6KKG · UniProt Q9WVQ1 · UniProt Q80TS7
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