MolNFT v1 · #154588 · protein
Cryo-EM structure of the mammalian tactile channel PIEZO2
6KG7 · Piezo-type mechanosensitive ion channel component 2: “Cryo-EM structure of the mammalian tactile channel PIEZO2”. Electron microscopy, 1 ligand (NAG), 20 pockets (best druggability 0.81). MolNFT v1 #154588 on GenesisL1: 3D…
- PDB
- 6KG7
- Type
- protein
- Length
- 5,451 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Piezo-type mechanosensitive ion channel component 2
- UniProt
- Q8CD54
- Ligands
- NAG
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 61% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Piezo-type mechanosensitive ion channel component 2 | protein | 1817 | 61% helix, 4% strand | Q8CD54 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 12 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1041 | 0.81 | 0.81 | 76 | empty |
| 2 | 1076 | 0.81 | 0.82 | 70 | empty |
| 3 | 1073 | 0.81 | 0.81 | 75 | empty |
| 4 | 595 | 0.79 | 0.85 | 52 | empty |
| 5 | 613 | 0.79 | 0.84 | 53 | empty |
Interfaces
3 interfaces between chains.
- A–B · 3201 Ų buried · 47 hydrogen bonds · protein-protein
- A–C · 3201 Ų buried · 46 hydrogen bonds · protein-protein
- B–C · 3196 Ų buried · 46 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 glycan, 3 disulfide (N-glycosylation, disulfide).
Compared structures
- 6KG7 · Cryo-EM Structure of the Mammalian Tactile Channel Piezo2 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8CD54
- Elsewhere: RCSB PDB 6KG7 · PDBe 6KG7 · UniProt Q8CD54
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