MolNFT v1 · #154566 · protein

Undocked hemichannel of an N-terminal deletion mutant of inx-6 in a nanodisc

6KFH · Innexin-6: “Undocked hemichannel of an N-terminal deletion mutant of inx-6 in a nanodisc”. Electron microscopy, 20 pockets (best druggability 0.79). MolNFT v1 #154566 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6KFH
Type: protein
Length: 2,544 residues
Chains: 8
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Innexin-6
UniProt: Q9U3N4
Pockets: 20 · best druggability 0.79

Structure

electron microscopy · 1 distinct chain · 62% helix, 2% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Innexin-6	protein	318	62% helix, 2% strand	Q9U3N4

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1047	0.79	0.80	127	empty
2	1136	0.79	0.80	131	empty
3	852	0.71	0.76	63	empty
4	786	0.71	0.76	61	empty
5	771	0.70	0.76	57	empty

Interfaces

8 interfaces between chains.

B–C · 1688 Å² buried · 14 hydrogen bonds · protein-protein
E–F · 1681 Å² buried · 12 hydrogen bonds · protein-protein
A–H · 1677 Å² buried · 12 hydrogen bonds · protein-protein
A–B · 1676 Å² buried · 12 hydrogen bonds · protein-protein
G–H · 1675 Å² buried · 14 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

6KFH · Undocked hemichannel of an N-terminal deletion mutant of INX-6 in a nanodisc · the same entry in another collection · chain H against H, TM-score 1.00
Q9U3N4 · AlphaFold monomer V2.0 prediction for innexin-6 (Q9U3N4) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U3N4
Elsewhere: RCSB PDB 6KFH · PDBe 6KFH · UniProt Q9U3N4

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