MolNFT v1 · #154565 · protein
Undocked inx-6 hemichannel in detergent
6KFG · Innexin-6: “Undocked inx-6 hemichannel in detergent”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #154565 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6KFG
- Type
- protein
- Length
- 2,704 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Innexin-6
- UniProt
- Q9U3N4
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 60% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H | Innexin-6 | protein | 338 | 60% helix, 4% strand | Q9U3N4 |
Pockets
20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 937 | 0.85 | 0.86 | 118 | empty |
| 2 | 626 | 0.81 | 0.86 | 83 | empty |
| 3 | 513 | 0.79 | 0.86 | 64 | empty |
| 4 | 985 | 0.77 | 0.79 | 93 | empty |
| 5 | 994 | 0.76 | 0.78 | 81 | empty |
Interfaces
8 interfaces between chains.
- C–D · 1736 Ų buried · 10 hydrogen bonds · protein-protein
- F–G · 1699 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 1699 Ų buried · 8 hydrogen bonds · protein-protein
- A–H · 1699 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 1694 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9U3N4
- Elsewhere: RCSB PDB 6KFG · PDBe 6KFG · UniProt Q9U3N4
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