MolNFT v1 · #154488 · protein + DNA

Crystal structure of hiran domain of hltf in complex with duplex DNA

6KCS · Helicase-like transcription factor: “Crystal structure of hiran domain of hltf in complex with duplex DNA”. X-ray diffraction, 1 pocket (best druggability 0.27). MolNFT v1 #154488 on GenesisL1: 3D structure, binding sites and…

PDB: 6KCS
Type: protein + DNA
Length: 129 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Helicase-like transcription factor; DNA (5'-D(*AP*CP*TP*GP*TP*AP*CP*GP*TP*AP*CP*AP*GP*T)-3…
EC: 2.3.2.27, 3.6.4.-
UniProt: Q14527
Pockets: 1 · best druggability 0.27

Structure

x-ray diffraction · 2 distinct chains · 23% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Helicase-like transcription factor (EC 2.3.2.27, 3.6.4.-)	protein	117	23% helix, 37% strand	Q14527
B	DNA (5'-D(APCPTPGPTPAPCPGPTPAPCPAPGPT)-3')	dna	12	—	—

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	54	0.27	0.74	13	empty

Interfaces

1 interface between chains.

A–B · 478 Å² buried · 7 hydrogen bonds · protein-nucleic

Compared structures

6KCS · Crystal structure of HIRAN domain of HLTF in complex with duplex DNA · the same entry in another collection · chain A against A, TM-score 1.00
Q14527 · AlphaFold monomer V2.0 prediction for helicase-like transcription factor (Q14527) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q14527
Elsewhere: RCSB PDB 6KCS · PDBe 6KCS · UniProt Q14527

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