MolNFT v1 · #154479 · protein
Structure of inosine 5'-monophosphate dehydrogenase from candidatus liberibacter asiaticus str. PSY62
6KCF · Inosine-5'-monophosphate dehydrogenase: “Structure of inosine 5'-monophosphate dehydrogenase from candidatus liberibacter asiaticus str. PSY62”. X-ray diffraction, 16 pockets (best druggability 0.66). MolNFT v1 #154479 on GenesisL1…
- PDB
- 6KCF
- Type
- protein
- Length
- 1,135 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inosine-5'-monophosphate dehydrogenase
- EC
- 1.1.1.205
- UniProt
- C6XG59
- Pockets
- 16 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 39% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 286 | 41% helix, 19% strand | C6XG59 |
| C | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 280 | 40% helix, 18% strand | C6XG59 |
| D | Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) | protein | 283 | 37% helix, 19% strand | C6XG59 |
Pockets
16 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 507 | 0.66 | 0.77 | 59 | empty |
| 2 | 347 | 0.62 | 0.78 | 44 | empty |
| 3 | 294 | 0.51 | 0.74 | 38 | empty |
| 4 | 243 | 0.49 | 0.74 | 37 | empty |
| 5 | 120 | 0.44 | 0.77 | 16 | empty |
Interfaces
3 interfaces between chains.
- C–D · 1156 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 1151 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 155 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 6KCF · Structure of Inosine 5'-monophosphate Dehydrogenase from Candidatus Liberibacter… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C6XG59
- Elsewhere: RCSB PDB 6KCF · PDBe 6KCF · UniProt C6XG59
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