MolNFT v1 · #154289 · protein
Application of anti-helix antibodies in protein structure determination (8188CYS-3LRHCYS)
6K6A · 3LRH intrabody: “Application of anti-helix antibodies in protein structure determination (8188CYS-3LRHCYS)”. X-ray diffraction, 3 pockets (best druggability 0.61). MolNFT v1 #154289 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6K6A
- Type
- protein
- Length
- 331 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3LRH intrabody; Engineered protein a
- Pockets
- 3 · best druggability 0.61
Structure
x-ray diffraction · 3 distinct chains · 43% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | 3LRH intrabody | protein | 109 | 3% helix, 50% strand | — |
| C | Engineered protein a | protein | 59 | 81% helix, 0% strand | — |
| D | Engineered protein a | protein | 54 | 83% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 374 | 0.61 | 0.77 | 33 | empty |
| 2 | 231 | 0.53 | 0.77 | 27 | empty |
| 3 | 218 | 0.49 | 0.75 | 30 | empty |
Interfaces
4 interfaces between chains.
- B–C · 690 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 635 Ų buried · 0 hydrogen bonds · protein-protein
- B–A · 293 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 244 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6K6A · Application of anti-helix antibodies in protein structure determination (8188cys-3LRHcys) · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6K6A · PDBe 6K6A
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