MolNFT v1 · #154287 · protein
Application of anti-helix antibodies in protein structure determination (8420-3MNZ)
6K68 · 3MNZ variable heavy chain: “Application of anti-helix antibodies in protein structure determination (8420-3MNZ)”. X-ray diffraction, 14 pockets (best druggability 0.67). MolNFT v1 #154287 on GenesisL1: 3D structure, binding sites…
- PDB
- 6K68
- Type
- protein
- Length
- 1,089 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3MNZ variable heavy chain; 3MNZ variable light chain; Protein a
- Pockets
- 14 · best druggability 0.67
Structure
x-ray diffraction · 4 distinct chains · 15% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, F | 3MNZ variable heavy chain | protein | 110 | 11% helix, 53% strand | — |
| B, D, G, K | 3MNZ variable light chain | protein | 112 | 3% helix, 46% strand | — |
| E, H, I, L | Protein a | protein | 50 | 66% helix, 2% strand | — |
| J | 3MNZ variable heavy chain | protein | 111 | 8% helix, 52% strand | — |
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 705 | 0.67 | 0.75 | 82 | empty |
| 2 | 376 | 0.60 | 0.77 | 26 | empty |
| 3 | 285 | 0.53 | 0.75 | 52 | empty |
| 4 | 185 | 0.47 | 0.76 | 26 | empty |
| 5 | 182 | 0.47 | 0.76 | 31 | empty |
Interfaces
17 interfaces between chains.
- J–K · 707 Ų buried · 5 hydrogen bonds · protein-protein
- F–G · 691 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 684 Ų buried · 4 hydrogen bonds · protein-protein
- C–D · 672 Ų buried · 5 hydrogen bonds · protein-protein
- J–L · 500 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 6K68 · Application of anti-helix antibodies in protein structure determination (8420-3MNZ) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 6K68 · PDBe 6K68
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