MolNFT v1 · #154067 · protein

B-glucuronidase from ruminococcus gnavus in complex with C6- substituted uronic isofagomine

6JZ6 · Beta-glucuronidase: “B-glucuronidase from ruminococcus gnavus in complex with C6- substituted uronic isofagomine”. X-ray diffraction, 1 ligand (CKX), 10 pockets (best druggability 0.85). MolNFT v1 #154067 on GenesisL1: 3D structure…

PDB: 6JZ6
Type: protein
Length: 1,160 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-glucuronidase
UniProt: Q6W7J7
Ligands: CKX
Pockets: 10 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Beta-glucuronidase	protein	580	21% helix, 35% strand	Q6W7J7

Ligands and binding sites

CKX · (2~{S},3~{S},4~{R},5~{R})-4,5-bis(oxidanyl)-2-propyl-piperidine-3-carboxylic acid · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	862	0.85	0.87	79	empty
2	691	0.71	0.78	88	empty
3	264	0.57	0.78	33	CKX
4	231	0.56	0.78	33	CKX
5	54	0.54	0.89	23	empty

Interfaces

1 interface between chains.

A–B · 1611 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

6JZ6 · b-glucuronidase from Ruminococcus gnavus in complex with C6-substituted uronic isofagomine · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6W7J7
Elsewhere: RCSB PDB 6JZ6 · PDBe 6JZ6 · UniProt Q6W7J7

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.