MolNFT v1 · #154062 · protein

Apo structure of B-glucuronidase from ruminococcus gnavus at 1.7 ångström resolution

6JZ1 · Beta-glucuronidase: “Apo structure of B-glucuronidase from ruminococcus gnavus at 1.7 ångström resolution”. X-ray diffraction, 12 pockets (best druggability 0.86). MolNFT v1 #154062 on GenesisL1: 3D structure, binding sites and…

PDB: 6JZ1
Type: protein
Length: 1,159 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-glucuronidase
UniProt: Q6W7J7
Pockets: 12 · best druggability 0.86

Structure

x-ray diffraction · 2 distinct chains · 21% helix, 35% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-glucuronidase	protein	574	21% helix, 35% strand	Q6W7J7
B	Beta-glucuronidase	protein	585	22% helix, 34% strand	Q6W7J7

Ligands and binding sites

MRD · (4R)-2-methylpentane-2,4-diol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1069	0.86	0.87	86	empty
2	695	0.71	0.78	82	empty
3	197	0.69	0.87	21	MRD
4	429	0.67	0.79	38	empty
5	65	0.52	0.86	23	empty

Interfaces

1 interface between chains.

A–B · 1621 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

6JZ1 · Apo structure of b-glucuronidase from Ruminococcus gnavus at 1.7 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6W7J7
Elsewhere: RCSB PDB 6JZ1 · PDBe 6JZ1 · UniProt Q6W7J7

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