MolNFT v1 · #153900 · protein

Aspergillus oryzae active-tyrosinase copper-depleted C92A mutant

6JU6: “Aspergillus oryzae active-tyrosinase copper-depleted C92A mutant”. X-ray diffraction, 1 ligand (NO3), 10 pockets (best druggability 0.65). MolNFT v1 #153900 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JU6
Type: protein
Length: 866 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosinase
EC: 1.14.18.1
UniProt: A0A1S9DK56
Ligands: NO3
Pockets: 10 · best druggability 0.65

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosinase (EC 1.14.18.1)	protein	437	42% helix, 12% strand	A0A1S9DK56
B	Tyrosinase (EC 1.14.18.1)	protein	429	42% helix, 10% strand	A0A1S9DK56

Ligands and binding sites

NO3 · Nitrate ion · ion · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	577	0.65	0.76	59	empty
2	392	0.62	0.77	54	empty
3	66	0.55	0.88	25	empty
4	61	0.46	0.83	20	empty
5	82	0.46	0.81	17	empty

Interfaces

1 interface between chains.

A–B · 1541 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

6JU6 · Aspergillus oryzae active-tyrosinase copper-depleted C92A mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A1S9DK56
Elsewhere: RCSB PDB 6JU6 · PDBe 6JU6 · UniProt A0A1S9DK56

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