MolNFT v1 · #153889 · protein
Crystal structure of HLA-C08 in complex with a tumor MUT10M peptide
6JTN · HLA class I antigen, CW8.2 alpha chain: “Crystal structure of HLA-C08 in complex with a tumor MUT10M peptide”. X-ray diffraction, 3 pockets (best druggability 0.68). MolNFT v1 #153889 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6JTN
- Type
- protein
- Length
- 381 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I antigen, CW8.2 alpha chain; Beta-2-microglobulin; 10-mer peptide
- UniProt
- C1K0Y1, P61769
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 21% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I antigen, CW8.2 alpha chain | protein | 273 | 29% helix, 40% strand | C1K0Y1 |
| B | Beta-2-microglobulin | protein | 98 | 0% helix, 50% strand | P61769 |
| C | 10-mer peptide | protein | 10 | 0% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 594 | 0.68 | 0.77 | 50 | empty |
| 2 | 159 | 0.50 | 0.78 | 32 | empty |
| 3 | 151 | 0.46 | 0.76 | 24 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1197 Ų buried · 21 hydrogen bonds · protein-protein
- A–C · 781 Ų buried · 21 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C1K0Y1
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 6JTN · PDBe 6JTN · UniProt C1K0Y1 · UniProt P61769
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