MolNFT v1 · #153879 · protein
Crystal structure of D464A L465A mutant of fgam synthetase
6JTA · Phosphoribosylformylglycinamidine synthase: “Crystal structure of D464A L465A mutant of fgam synthetase”. X-ray diffraction, 4 ligands (ADP, GLN, MG), 10 pockets (best druggability 0.86). MolNFT v1 #153879 on GenesisL1: 3D…
- PDB
- 6JTA
- Type
- protein
- Length
- 1,298 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphoribosylformylglycinamidine synthase
- EC
- 6.3.5.3
- UniProt
- A0A0D6F9Y3
- Ligands
- ADP, GLN, MG, SO4
- Pockets
- 10 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphoribosylformylglycinamidine synthase (EC 6.3.5.3) | protein | 1298 | 35% helix, 27% strand | A0A0D6F9Y3 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- GLN · Glutamine · ligand · chains A
- MG · Magnesium ion · metal · 3 copies · chains A
- SO4 · Sulfate ion · ion · 18 copies · chains A
- EDO · 1,2-ethanediol · additive · 23 copies · chains A
- GOL · Glycerol · additive · 12 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 292 | 0.86 | 0.97 | 45 | ADP, MG |
| 2 | 998 | 0.83 | 0.84 | 96 | EDO, SO4 |
| 3 | 712 | 0.80 | 0.84 | 93 | GOL, EDO, SO4 |
| 4 | 284 | 0.79 | 0.91 | 34 | GOL |
| 5 | 122 | 0.79 | 0.98 | 32 | empty |
Compared structures
- 6JTA · Crystal Structure of D464A L465A mutant of FGAM Synthetase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A0D6F9Y3
- Elsewhere: RCSB PDB 6JTA · PDBe 6JTA · UniProt A0A0D6F9Y3
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