MolNFT v1 · #153793 · protein

Cryoem structure of ABO1 hexamer - apo complex

6JPU · Uncharacterized aaa domain-containing protein C31G5.19: “Cryoem structure of ABO1 hexamer - apo complex”. Electron microscopy, 20 pockets (best druggability 0.84). MolNFT v1 #153793 on GenesisL1: 3D structure, binding sites and…

PDB: 6JPU
Type: protein
Length: 3,462 residues
Chains: 6
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uncharacterized aaa domain-containing protein C31G5.19
UniProt: O14114
Pockets: 20 · best druggability 0.84

Structure

electron microscopy · 1 distinct chain · 39% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Uncharacterized aaa domain-containing protein C31G5.19	protein	577	39% helix, 7% strand	O14114

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	965	0.84	0.85	136	empty
2	1074	0.83	0.84	105	empty
3	1090	0.82	0.83	110	empty
4	966	0.82	0.84	95	empty
5	1156	0.82	0.83	111	empty

Interfaces

6 interfaces between chains.

B–C · 4167 Å² buried · 24 hydrogen bonds · protein-protein
E–F · 3835 Å² buried · 18 hydrogen bonds · protein-protein
C–D · 3551 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 3293 Å² buried · 22 hydrogen bonds · protein-protein
D–E · 3261 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

6JPU · CryoEM structure of Abo1 hexamer - apo complex · the same entry in another collection · chain F against F, TM-score 1.00
O14114 · AlphaFold monomer V2.0 prediction for uncharacterized aaa domain- containing protein… · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14114
Elsewhere: RCSB PDB 6JPU · PDBe 6JPU · UniProt O14114

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