MolNFT v1 · #153780 · protein

Structure of ATOSCA1.1 channel at 3.52A

6JPF · Protein OSCA1: “Structure of ATOSCA1.1 channel at 3.52A”. Electron microscopy, 12 pockets (best druggability 0.74). MolNFT v1 #153780 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JPF
Type: protein
Length: 1,220 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein OSCA1
UniProt: Q9XEA1
Pockets: 12 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 69% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protein OSCA1	protein	610	69% helix, 4% strand	Q9XEA1

Pockets

12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	635	0.74	0.80	57	empty
2	667	0.73	0.80	64	empty
3	474	0.66	0.78	62	empty
4	435	0.63	0.77	48	empty
5	115	0.53	0.81	26	empty

Interfaces

1 interface between chains.

A–B · 1379 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6JPF · Structure of atOSCA1.1 channel at 3.52A · the same entry in another collection · chain A against A, TM-score 1.00
Q9XEA1 · AlphaFold monomer V2.0 prediction for protein OSCA1 (Q9XEA1) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9XEA1
Elsewhere: RCSB PDB 6JPF · PDBe 6JPF · UniProt Q9XEA1

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