MolNFT v1 · #153541 · protein
The complex crystal structure of cagbeta with cagz revealed a novel regulatory mechanism for T4SS coupling ATPase in helicobacter pylori
6JHO · Cag pathogenicity island protein (CAG6): “The complex crystal structure of cagbeta with cagz revealed a novel regulatory mechanism for T4SS coupling…”. X-ray diffraction, 8 pockets (best druggability 0.74). MolNFT v1 #153541 on…
- PDB
- 6JHO
- Type
- protein
- Length
- 749 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cag pathogenicity island protein (CAG6); Cag pathogenicity island protein (CAG5)
- UniProt
- O25261, O25260
- Pockets
- 8 · best druggability 0.74
Structure
x-ray diffraction · 3 distinct chains · 62% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Cag pathogenicity island protein (CAG6) | protein | 200 | 77% helix, 0% strand | O25261 |
| C | Cag pathogenicity island protein (CAG5) | protein | 175 | 55% helix, 5% strand | O25260 |
| D | Cag pathogenicity island protein (CAG5) | protein | 174 | 53% helix, 5% strand | O25260 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 539 | 0.74 | 0.82 | 54 | empty |
| 2 | 504 | 0.74 | 0.82 | 51 | empty |
| 3 | 112 | 0.66 | 0.89 | 33 | empty |
| 4 | 149 | 0.59 | 0.84 | 38 | empty |
| 5 | 93 | 0.44 | 0.79 | 16 | empty |
Interfaces
5 interfaces between chains.
- B–D · 2312 Ų buried · 37 hydrogen bonds · protein-protein
- A–C · 2303 Ų buried · 38 hydrogen bonds · protein-protein
- A–B · 633 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 213 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 212 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 6JHO · The complex crystal structure of Cagbeta with CagZ revealed a novel regulatory mechanism… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O25261
- Every structure of UniProt O25260
- Elsewhere: RCSB PDB 6JHO · PDBe 6JHO · UniProt O25261 · UniProt O25260
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