MolNFT v1 · #153524 · protein

Crystal structure of BISG15/NS1B complex

6JH1 · Non-structural protein 1: “Crystal structure of BISG15/NS1B complex”. X-ray diffraction, 4 pockets (best druggability 0.70). MolNFT v1 #153524 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JH1
Type: protein
Length: 477 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 1; Ubiquitin-like protein ISG15
UniProt: P03502, O02741
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 3 distinct chains · 49% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Non-structural protein 1	protein	92	72% helix, 0% strand	P03502
B	Non-structural protein 1	protein	91	73% helix, 0% strand	P03502
D, C	Ubiquitin-like protein ISG15	protein	147	20% helix, 33% strand	O02741

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	834	0.70	0.76	76	empty
2	614	0.66	0.76	63	empty
3	180	0.59	0.82	19	empty
4	55	0.32	0.76	21	empty

Interfaces

5 interfaces between chains.

A–B · 1907 Å² buried · 25 hydrogen bonds · protein-protein
A–C · 624 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 614 Å² buried · 9 hydrogen bonds · protein-protein
B–D · 596 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 493 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

6JH1 · Crystal structure of bISG15/NS1B complex · the same entry in another collection · chain A against A, TM-score 1.00
O02741 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein ISG15 (O02741) · a predicted model of the same protein · chain D against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P03502
Every structure of UniProt O02741
Elsewhere: RCSB PDB 6JH1 · PDBe 6JH1 · UniProt P03502 · UniProt O02741

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.