MolNFT v1 · #153359 · protein
Structural analysis of molybdopterin synthases from two mycobacteria pathogens
6JC0 · Putative molybdenum cofactor biosynthesis protein: “Structural analysis of molybdopterin synthases from two mycobacteria pathogens”. X-ray diffraction, 5 pockets (best druggability 0.54). MolNFT v1 #153359 on GenesisL1: 3D…
- PDB
- 6JC0
- Type
- protein
- Length
- 446 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative molybdenum cofactor biosynthesis protein; Putative molybdenum cofactor…
- UniProt
- I7FL16, I7FT00
- Pockets
- 5 · best druggability 0.54
Structure
x-ray diffraction · 3 distinct chains · 29% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Putative molybdenum cofactor biosynthesis protein | protein | 137 | 29% helix, 43% strand | I7FL16 |
| C, A | Putative molybdenum cofactor biosynthesis protein D2 (MOAD2) / thiamine S | protein | 84 | 26% helix, 37% strand | I7FT00 |
| D | Putative molybdenum cofactor biosynthesis protein | protein | 141 | 30% helix, 42% strand | I7FL16 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 161 | 0.54 | 0.80 | 25 | empty |
| 2 | 174 | 0.54 | 0.79 | 26 | empty |
| 3 | 76 | 0.35 | 0.76 | 17 | empty |
| 4 | 74 | 0.34 | 0.75 | 19 | empty |
| 5 | 64 | 0.30 | 0.74 | 14 | empty |
Interfaces
3 interfaces between chains.
- B–D · 1017 Ų buried · 18 hydrogen bonds · protein-protein
- C–D · 764 Ų buried · 10 hydrogen bonds · protein-protein
- B–A · 761 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6JC0 · Structural analysis of molybdopterin synthases from two mycobacteria pathogens · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I7FL16
- Every structure of UniProt I7FT00
- Elsewhere: RCSB PDB 6JC0 · PDBe 6JC0 · UniProt I7FL16 · UniProt I7FT00
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