MolNFT v1 · #153294 · protein

Coiled-coil domain of drosophila trim protein brat

6J9R · Brain tumor protein: “Coiled-coil domain of drosophila trim protein brat”. X-ray diffraction, 1 pocket (best druggability 0.31). MolNFT v1 #153294 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J9R
Type: protein
Length: 251 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Brain tumor protein
UniProt: Q8MQJ9
Pockets: 1 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 90% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Brain tumor protein	protein	125	91% helix, 0% strand	Q8MQJ9
B	Brain tumor protein	protein	126	88% helix, 0% strand	Q8MQJ9

Ligands and binding sites

GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	57	0.31	0.76	16	empty

Interfaces

1 interface between chains.

A–B · 2578 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 modified (engineered).

Compared structures

6J9R · Coiled-coil Domain of Drosophila TRIM Protein Brat · the same entry in another collection · chain A against A, TM-score 1.00
Q8MQJ9 · AlphaFold monomer V2.0 prediction for brain tumor protein (Q8MQJ9) · a predicted model of the same protein · chain A against A, TM-score 0.79

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8MQJ9
Elsewhere: RCSB PDB 6J9R · PDBe 6J9R · UniProt Q8MQJ9

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