GL1X · GenesisL1 explorer

MolNFT v1 · #153280 · protein + DNA

Arabidopsis FUS3-DNA complex

6J9B · B3 domain-containing transcription factor FUS3: “Arabidopsis FUS3-DNA complex”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #153280 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
6J9B
Type
protein + DNA
Length
272 residues
Chains
6
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
B3 domain-containing transcription factor FUS3; DNA…
UniProt
Q9LW31
Pockets
2 · best druggability 0.38

Structure

x-ray diffraction · 3 distinct chains · 17% helix, 43% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
A, DB3 domain-containing transcription factor FUS3protein10617% helix, 43% strandQ9LW31
C, FDNA (5'-D(*AP*AP*TP*CP*CP*AP*TP*GP*CP*AP*GP*AP*AP*TP*C)- 3')dna15——
B, EDNA (5'-D(*AP*TP*TP*CP*TP*GP*CP*AP*TP*GP*GP*AP*TP*TP*G)- 3')dna15——

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1900.380.7719empty
2590.330.7713empty

Interfaces

7 interfaces between chains.

  • C–B · 686 Ų buried · 57 hydrogen bonds · nucleic-nucleic
  • F–E · 666 Ų buried · 58 hydrogen bonds · nucleic-nucleic
  • A–C · 482 Ų buried · 10 hydrogen bonds · protein-nucleic
  • D–F · 428 Ų buried · 6 hydrogen bonds · protein-nucleic
  • A–B · 387 Ų buried · 6 hydrogen bonds · protein-nucleic

Compared structures

  • 6J9B · Arabidopsis FUS3-DNA complex · the same entry in another collection · chain E against E, TM-score 1.00
  • Q9LW31 · AlphaFold monomer V2.0 prediction for B3 domain-containing transcription factor FUS3… · a predicted model of the same protein · chain D against A, TM-score 0.99

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