MolNFT v1 · #153184 · protein

Crystal structure of MISG15/NS1B complex

6J62 · Ubiquitin-like protein ISG15: “Crystal structure of MISG15/NS1B complex”. X-ray diffraction, 2 pockets (best druggability 0.30). MolNFT v1 #153184 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J62
Type: protein
Length: 242 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-like protein ISG15; Non-structural protein 1
UniProt: Q64339, P03502
Pockets: 2 · best druggability 0.30

Structure

x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin-like protein ISG15	protein	150	23% helix, 37% strand	Q64339
C	Non-structural protein 1	protein	92	67% helix, 0% strand	P03502

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	58	0.30	0.75	15	empty
2	53	0.27	0.73	16	empty

Interfaces

1 interface between chains.

A–C · 450 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

6J62 · Crystal structure of mISG15/NS1B complex · the same entry in another collection · chain A against A, TM-score 1.00
Q64339 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein ISG15 (Q64339) · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q64339
Every structure of UniProt P03502
Elsewhere: RCSB PDB 6J62 · PDBe 6J62 · UniProt Q64339 · UniProt P03502

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