MolNFT v1 · #153161 · protein

Complex structure of mab 4.2-scfv with louping ill virus envelope protein domain III

6J5D: “Complex structure of mab 4.2-scfv with louping ill virus envelope protein domain III”. X-ray diffraction, 2 pockets (best druggability 0.43). MolNFT v1 #153161 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J5D
Type: protein
Length: 322 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Envelope; Antibody heavy chain; Antibody light chain
UniProt: O40970
Pockets: 2 · best druggability 0.43

Structure

x-ray diffraction · 3 distinct chains · 5% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Envelope	protein	94	0% helix, 54% strand	O40970
H	Antibody heavy chain	protein	120	10% helix, 50% strand	—
L	Antibody light chain	protein	108	3% helix, 49% strand	—

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.43	0.74	32	empty
2	115	0.40	0.76	27	empty

Interfaces

3 interfaces between chains.

H–L · 832 Å² buried · 10 hydrogen bonds · protein-protein
A–H · 377 Å² buried · 10 hydrogen bonds · protein-protein
A–L · 322 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

6J5D · Complex structure of MAb 4.2-scFv with louping ill virus envelope protein Domain III · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O40970
Elsewhere: RCSB PDB 6J5D · PDBe 6J5D · UniProt O40970

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