MolNFT v1 · #153122 · protein

Glycine mutation on single layer beta-sheet of OSPASM1

6J48 · Outer surface protein a: “Glycine mutation on single layer beta-sheet of OSPASM1”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1 #153122 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J48
Type: protein
Length: 246 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Outer surface protein a
UniProt: P0CL66
Pockets: 2 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 3% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
O	Outer surface protein a	protein	246	3% helix, 54% strand	P0CL66

Ligands and binding sites

PG4 · Tetraethylene glycol · additive · 2 copies · chains O

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.29	0.74	15	PG4
2	65	0.29	0.73	17	PG4

Compared structures

6J48 · Glycine mutation on single layer beta-sheet of OspAsm1 · the same entry in another collection · chain O against O, TM-score 1.00
P0CL66 · AlphaFold monomer V2.0 prediction for outer surface protein a (P0CL66) · a predicted model of the same protein · chain O against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0CL66
Elsewhere: RCSB PDB 6J48 · PDBe 6J48 · UniProt P0CL66

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