MolNFT v1 · #153001 · protein

Crystal structure of human majin and TERB2

6J08 · Membrane-anchored junction protein: “Crystal structure of human majin and TERB2”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #153001 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6J08
Type: protein
Length: 411 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Membrane-anchored junction protein; Telomere repeats-binding bouquet formation protein 2
UniProt: Q3KP22, Q8NHR7
Pockets: 4 · best druggability 0.73

Structure

x-ray diffraction · 6 distinct chains · 14% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Membrane-anchored junction protein	protein	103	16% helix, 47% strand	Q3KP22
D	Telomere repeats-binding bouquet formation protein 2	protein	36	8% helix, 28% strand	Q8NHR7
B	Membrane-anchored junction protein	protein	103	16% helix, 47% strand	Q3KP22
E	Telomere repeats-binding bouquet formation protein 2	protein	31	10% helix, 29% strand	Q8NHR7
C	Membrane-anchored junction protein	protein	104	15% helix, 46% strand	Q3KP22
F	Telomere repeats-binding bouquet formation protein 2	protein	34	9% helix, 24% strand	Q8NHR7

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	399	0.73	0.84	49	empty
2	356	0.61	0.77	36	empty
3	68	0.45	0.82	20	empty
4	109	0.43	0.77	21	empty

Interfaces

10 interfaces between chains.

B–E · 1351 Å² buried · 26 hydrogen bonds · protein-protein
C–F · 1333 Å² buried · 24 hydrogen bonds · protein-protein
A–D · 1319 Å² buried · 26 hydrogen bonds · protein-protein
B–C · 542 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 371 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

6J08 · Crystal structure of human MAJIN and TERB2 · the same entry in another collection · chain F against F, TM-score 1.00
Q3KP22 · AlphaFold monomer V2.0 prediction for membrane-anchored junction protein (Q3KP22) · a predicted model of the same protein · chain C against A, TM-score 0.39
Q8NHR7 · AlphaFold monomer V2.0 prediction for telomere repeats-binding bouquet formation protein… · a predicted model of the same protein · chain D against A, TM-score 0.32

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3KP22
Every structure of UniProt Q8NHR7
Elsewhere: RCSB PDB 6J08 · PDBe 6J08 · UniProt Q3KP22 · UniProt Q8NHR7

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